Anita Shukla

Biography:

Anita Shukla is currently an NIH Ruth Kirschstein postdoctoral fellow.  Dr. Shukla's postoctoral research focuses on designing biologically inspired micropatterned surfaces to direct stem cell differentiation.  She received her Ph.D. in Chemical Engineering in 2011 from the Massachusetts Institute of Technology as an NSF Graduate Research Fellow.  In her doctoral work, Dr. Shukla engineered local drug delivery coatings to treat infection, inflammation, and bleeding.  At MIT, Dr. Shukla also received a Master's of Science in Chemical Engineering Practice completing internships at GlaxoSmithKline and BASF.  Prior to this, Dr. Shukla received her Bachelor's degree at Carnegie Mellon University in 2006 with a double major in chemical engineering and biomedical engineering.

Research Interests:

As a postdoc, Dr. Shukla is designing protein micropatterned surfaces that mimic the shape and adhesion site morphology of various cells of the mesoderm lineage.  She subsequently uses these biomimetic surfaces to culture and study the differentation of bone marrow-derived mesenchymal stem cells.  In her graduate research, Dr. Shukla developed polymer multilayer films for the controlled local delivery of therapuetics aimed at alleviating infection, inflammation and bleeding.  In her future independent research group, Dr. Shukla will develop smart biomaterials to address a variety of unmet needs in the areas of drug delivery and regenerative medicine.  Dr. Shukla will apply concepts from polymer self-assembly, cellular mechanobiology, and the study of moelcular interactions to design materials to study and treat human injury and disease.

Contact Information:

Email: anita.shukla@rice.edu

Publications:

Journal Publications:

 Shukla, A., Fang, J.C., Puranam, S., Jensen, F.R., and Hammond, P.T. Hemostatic multilayer coatings, Advanced Materials, 24(4), 492-496, 2012. (Featured in MIT Research Spotlight, Forbes Magazine, Popular Science, etc.) 

 

Shukla, A., Fang, J.C., Puranam, S., and Hammond, P.T. Release of vancomycin from multilayer coated absorbent gelatin sponges, Journal of Controlled Release, 157(1), 64-71, 2012.

Shukla, A., Puranam, S., and Hammond, P.T. Vancomycin storage stability in multilayer thin film coatings for on-demand care, Journal of Biomaterials Science, Polymer Edition, 23(15), 1895-1902, 2012.

 Shukla, A.*, Fuller, R.C.*, and Hammond, P.T. Design of multi-drug release coatings targeting infection and inflammation, Journal of Controlled Release, 155(2), 159-166, 2011. *Co-first authors

 Samuel, R.E.*, Shukla, A.*, Paik, D.H., Wang, M.X., Fang, J.C., Schmidt, D.J., and Hammond, P.T. Osteoconductive protamine-based polyelectrolyte multilayer functionalized surfaces, Biomaterials, 32(30), 7491-7502, 2011. *Co-first authors

 Engler, A.C.*, Shukla, A.*, Puranam, S., Buss, H.G, Jreige, N., and Hammond, P.T. Effects of side group functionality and molecular weight on the activity of synthetic antimicrobial polypeptides, Biomacromolecules, 12(5), 1666-1674, 2011. *Co-first authors

 

 Shukla, A., Avadhany, S.N., Fang, J.C., and Hammond, P.T. Tunable vancomycin releasing surfaces for biomedical applications, Small, 6(21), 2392-2404, 2010. (Featured in Materials Views)

 

Shukla, A., Fleming, K.E., Chuang, H.F., Chau, T.M., Loose, C.R., Stephanopoulos, G.N., and Hammond, P.T. Controlling the release of peptide antimicrobial agents from surfaces, Biomaterials, 31(8), 2348-2357, 2010.

 

Shukla, A., Dunn, A.R., Moses, M.A., and Van Vliet, K.J. Endothelial cells as mechanical transducers: enzymatic activity and network formation under cyclic strain, Mechanics and Chemistry of Biosystems, 1(4), 279-290, 2004.

Journal Publications (in preparation):

 Shukla, A. Application of layer-by-layer films in the study of cell behavior and design of tissue engineering therapies, Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology. (Review article; target submission: January 31, 2013)

 

Shukla, A. and Hammond, P.T. Layer-by-layer antimicrobial medical device coatings, Advanced Drug Delivery Reviews. (Invited review; target submission: January 31, 2013)

 

Monteiro, I.P., Shukla, A., Marques, A.P., Reis, R.L., and Hammond, P.T. Developing a single epidermal-dermal scaffold for skin tissue engineering using spray-assisted layer-by-layer assembly.

Book Chapter:

Yang, F., Neeley, W.L., Moore, M.J., Karp, J.M., Shukla, A., and Langer, R.S. Tissue engineering: the therapeutic strategy of the twenty-first century, Nanotechnology and Tissue Engineering, editors: C.T. Laurencin and L.S. Nair, CRC Press, pp. 3-32, 2008.