Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

TitleVascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials
Publication TypeJournal Article
Year of Publication2008
AuthorsWest, JL, Moon, JJ
JournalCurrent Topics in Medicinal Chemistry
Volume8
Issue4
Pagination300 - 310
Date Published03/2008
ISSN15680266
KeywordsAngiogenesis; Biomaterial; scaffold; Tissue Engineering; vascularization
Abstract

Although there have been extensive research efforts to create functional tissues and organs, most successes in tissue engineering have been limited to avascular or thin tissues. The major hurdle in development of more complex tissues lies in the formation of vascular networks capable of delivering oxygen and nutrients throughout the engineered constructs. Sufficient neovascularization in scaffold materials can be achieved through coordinated application of angiogenic factors with proper cell types in biomaterials. This review present the current research developments in the design of biomaterials and their biochemical and biochemical modifications to produce vascularized tissue constructs.

DOI10.2174/156802608783790983
Short TitleCurr Top Med Chem
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