Poly(ethylene glycol)-lysine dendrimers for targeted delivery of nitric oxide

TitlePoly(ethylene glycol)-lysine dendrimers for targeted delivery of nitric oxide
Publication TypeJournal Article
Year of Publication2006
AuthorsTaite, LJ, West, JL
JournalJournal of Biomaterials Science, Polymer Edition
Volume17
Issue10
Pagination1159 - 1172
Date Published01/2006
ISSN1568-5624
Keywordsdendrimer; diazeniumdiolate; nitric oxide; polyethylene glycol; Sialyl Lewis X; targeted drug delivery
Abstract

We have synthesized dendrimers of the amino-acid lysine bound to a central poly(ethylene glycol) (PEG) core, and then formed multiple diazeniumdiolate nitric oxide (NO) donors on the lysine residues. NO release from these materials occurred for up to 60 days under physiological conditions. These materials display the ability to regulate vascular cell proliferation and inhibit platelet adhesion to thrombogenic surfaces. When modified with a targeting ligand specific for inflamed endothelium (Sialyl Lewis X), we were able to demonstrate binding of fluorescently-labeled dendrimers to endothelial cells activated by interleukin 1 beta (IL-1 beta).

DOI10.1163/156856206778530696
Short TitleJournal of Biomaterials Science, Polymer Edition
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