|Title||Gadolinium-Conjugated Gold Nanoshells for Multimodal Diagnostic Imaging and Photothermal Cancer Therapy|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Coughlin, AJ, Ananta, JS, Deng, N, Larina, IV, Decuzzi, P, West, JL|
|Keywords||magnetic resonance imaging; optical imaging; photothermal therapy; X-ray imaging|
Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.