Gadolinium-Conjugated Gold Nanoshells for Multimodal Diagnostic Imaging and Photothermal Cancer Therapy

TitleGadolinium-Conjugated Gold Nanoshells for Multimodal Diagnostic Imaging and Photothermal Cancer Therapy
Publication TypeJournal Article
Year of Publication2014
AuthorsCoughlin, AJ, Ananta, JS, Deng, N, Larina, IV, Decuzzi, P, West, JL
JournalSmall
Pagination556-565
Date Published02/2014
Keywordsmagnetic resonance imaging; optical imaging; photothermal therapy; X-ray imaging
Abstract

Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.

DOI10.1002/smll.201302217
Short TitleSmall
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