Nitric oxide-generating hydrogels inhibit neointima formation

TitleNitric oxide-generating hydrogels inhibit neointima formation
Publication TypeJournal Article
Year of Publication2005
AuthorsBohl, KS, Lipke, EA, Rice, EEH, Liel, MS, Myler, HA, Zygourakis, C, Tulis, DA, West, JL
JournalJournal of Biomaterials Science, Polymer Edition
Volume16
Issue5
Pagination659 - 672
Date Published01/2005
ISSN1568-5624
KeywordsDrug delivery vehicle; hydrogels; nitric oxide; restenosis; S-nitrosocysteine; thrombosis
Abstract

This study evaluated the effects of localized delivery of nitric oxide (NO) from hydrogels covalently modified with S-nitrosocysteine (Cys-NO) on neoinitma formation, a key component of restenosis, in a rat balloon-injury model. Soluble Cys-NO was used in preliminary studies to identify dosage ranges that were able to simultaneously inhibit smooth muscle cell proliferation, enhance endothelial cell proliferation, and reduce platelet adhesion. Photo-cross-linked PEG-based hydrogels were formed with covalently immobilized Cys-NO. These materials release NO for approximately 24 h and can be applied to tissues and photo-cross-linked in situ to form local drug-delivery systems. Localized delivery of NO from hydrogels containing Cys-NO inhibited neointima formation in a rat balloon-injury model by approximately 75% at 14 days.

DOI10.1163/1568562053783722
Short TitleJ Biomater Sci Polym Ed
Full Text