Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles

TitlePhoto-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
Publication TypeJournal Article
Year of Publication2004
AuthorsO'Neal, DP, Hirsch, LR, Halas, N, Payne, JD, West, JL
JournalCancer Letters
Volume209
Issue2
Pagination171 - 176
Date Published6/2004
ISSN03043835
Keywordshyperthermia; Laser; Minimally invasive therapy; nanoshells; nanotechnology; near infrared
Abstract

The following study examines the feasibility of nanoshell-assisted photo-thermal therapy (NAPT). This technique takes advantage of the strong near infrared (NIR) absorption of nanoshells, a new class of gold nanoparticles with tunable optical absorptivities that can undergo passive extravasation from the abnormal tumor vasculature due to their nanoscale size. Tumors were grown in immune-competent mice by subcutaneous injection of murine colon carcinoma cells (CT26.WT). Polyethylene glycol (PEG) coated nanoshells (≈130 nm diameter) with peak optical absorption in the NIR were intravenously injected and allowed to circulate for 6 h. Tumors were then illuminated with a diode laser (808 nm, 4 W/cm2, 3 min). All such treated tumors abated and treated mice appeared healthy and tumor free >90 days later. Control animals and additional sham-treatment animals (laser treatment without nanoshell injection) were euthanized when tumors grew to a predetermined size, which occurred 6–19 days post-treatment. This simple, non-invasive procedure shows great promise as a technique for selective photo-thermal tumor ablation.

DOI10.1016/j.canlet.2004.02.004
Short TitleCancer Letters
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