|Title||ACS Symposium SeriesTherapeutic Protein and Peptide Formulation and DeliveryIn Situ Formation of Polymer Matrices for Localized Drug Delivery|
|Year of Publication||2009|
|Series Editor||Shahrokh, Z, Sluzky, V, Cleland, JL, Shire, SJ, Randolph, TW|
|Number of Pages||119 - 123|
|Publisher||American Chemical Society|
|Keywords||Drug delivery vehicle; in situ; Polymer|
Polymer matrices can be formed within the body in direct contact with cells and tissues by a variety of techniques, both physicochemical and covalent in nature, including thermal gelation, pH-sensitive gelation, the use of thixotropic materials, precipitation from certain organic solutions, photopolymerization, and chemical cross-linking. These types of materials can be injected as liquids and converted to a gel or solid in situ. Many of these polymer systems are appropriate for delivery of peptides and proteins.