ACS Symposium SeriesTherapeutic Protein and Peptide Formulation and DeliveryIn Situ Formation of Polymer Matrices for Localized Drug Delivery

TitleACS Symposium SeriesTherapeutic Protein and Peptide Formulation and DeliveryIn Situ Formation of Polymer Matrices for Localized Drug Delivery
Publication TypeBook
Year of Publication2009
AuthorsWest, JL
Series EditorShahrokh, Z, Sluzky, V, Cleland, JL, Shire, SJ, Randolph, TW
Volume675
Number of Pages119 - 123
PublisherAmerican Chemical Society
CityWashington, DC
ISBN Number0-8412-1639-8
KeywordsDrug delivery vehicle; in situ; Polymer
Abstract

Polymer matrices can be formed within the body in direct contact with cells and tissues by a variety of techniques, both physicochemical and covalent in nature, including thermal gelation, pH-sensitive gelation, the use of thixotropic materials, precipitation from certain organic solutions, photopolymerization, and chemical cross-linking. These types of materials can be injected as liquids and converted to a gel or solid in situ. Many of these polymer systems are appropriate for delivery of peptides and proteins.

DOI10.1021/bk-1997-0675.ch007
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