Comparison of covalently and physically cross-linked polyethylene glycol-based hydrogels for the prevention of postoperative adhesions in a rat model

TitleComparison of covalently and physically cross-linked polyethylene glycol-based hydrogels for the prevention of postoperative adhesions in a rat model
Publication TypeJournal Article
Year of Publication1995
AuthorsWest, JL, Hubbell, JA
JournalBiomaterials
Volume16
Issue15
Pagination1153 - 1156
Date Published10/1995
ISSN01429612
Keywordsadhesion prevention; hydrogels; photopolymerization; Poloxamer 407; polyethylene glycol
Abstract

A covalently and a physicochemically cross-linked hydrogel, both based primarily on polyethylene glycol and both formed in situ, were compared side by side in a rat uterine horn devascularization and serosal injury model for efficacy in adhesion prevention. The primary difference between the two materials was the nature of their cross-linking. The covalently cross-linked hydrogel was a photopolymerized polyethylene glycol-co-lactic acid diacrylate, and the physically cross-linked hydrogel was a polyethylene glycol-co-polypropylene glycol, Poloxamer 407®. In the surgical model employed, application of the covalently cross-linked hydrogel reduced the extent of adhesion formation from 75 ± 10% in the control group to 16 ± 6% (mean ± s.d., P < 0.001). Application of the physically crosslinked hydrogel reduced adhesion formation to 38 ± 19% (P < 0.01). Retention of the two hydrogels upon the site of application was also evaluated. The covalently cross-linked hydrogel formed a continuous barrier upon the uterine horns for more than 4 d, while the physicochemically cross-linked hydrogel was present upon the uterine horns for less than 2 d. This difference in retention was probably the cause of the difference in efficacy and may be attributed to the nature of the cross-linking.

DOI10.1016/0142-9612(95)93579-3
Short TitleBiomaterials
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