Photopolymerized hydrogel materials for drug delivery applications

TitlePhotopolymerized hydrogel materials for drug delivery applications
Publication TypeJournal Article
Year of Publication1995
AuthorsWest, JL, Hubbell, JA
JournalReactive Polymers
Volume25
Issue2-3
Pagination139 - 147
Date Published6/1995
ISSN09231137
KeywordsBioactive material; Drug delivery vehicle; Non-toxic precursor; Photopolymerized hydrogel; Water soluble
Abstract

A novel photopolymerized hydrogel material has been developed for use as a drug delivery vehicle for bioactive materials. The hydrogel precursor consists of polyethylene glycol copolymerized with an α-hydroxy acid and with acrylate termini at each end. The precursor is water-soluble and non-toxic. The precursor polymerization conditions are very mild, and polymerization can be carried out in direct contact with cells and tissues. The degradation rate and permeability of the hydrogel can be altered by changing the composition of the precursors, allowing use of this class of materials for a variety of applications. In vitro release of proteins and oligonucleotides is reported.

DOI10.1016/0923-1137(94)00096-N
Short TitleReact Polym
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