Efficacy of a resorbable hydrogel barrier, oxidized regenerated cellulose, and hyaluronic acid in the prevention of ovarian adhesions in a rabbit model

TitleEfficacy of a resorbable hydrogel barrier, oxidized regenerated cellulose, and hyaluronic acid in the prevention of ovarian adhesions in a rabbit model
Publication TypeJournal Article
Year of Publication1994
AuthorsWest, JL, Chowdhury, SM, Dunn, RC, Hubbell, JA
JournalFertility and Sterility
Volume62
Issue3
Pagination630-634
Date Published09/1994
Keywordsadhesion prevention; hyaluronic acid; hydrogels; ovary; regerated cellulose
Abstract

OBJECTIVE:
To compare the efficacy of a resorbable hydrogel material with oxidized regenerated cellulose and hyaluronic acid in an ovarian adhesion model.

DESIGN:
Controlled, blinded, and randomized study involving female rabbits.

SETTING:
Academic research environment.

INTERVENTIONS:
A water-soluble hydrogen precursor was applied to the ovary as a liquid and converted to a hydrogel by exposure to long wavelength ultraviolet light, a 0.4% solution of hyaluronic acid was applied to the ovary, or an oxidized regenerated cellulose patch was applied to the ovary after wedge resectioning.

MAIN OUTCOME MEASURES:
Extent and severity of adhesion formation.

RESULTS:
Application of the hydrogel reduced adhesion formation by 88%. Neither oxidized regenerated cellulose nor hyaluronic acid reduced adhesion formation.

CONCLUSION:
The photopolymerized, resorbable hydrogel material is highly effective for the reduction of periovarian adhesions in this model.

Short TitleFertil Steril
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