Molecular weight changes in polymer erosion

TitleMolecular weight changes in polymer erosion
Publication TypeJournal Article
Year of Publication1992
AuthorsD’Emanuele, A, Hill, JL, Tamada, JA, Domb, AJ, Langer, R
JournalPharmaceutical Research
Volume09
Issue10
Pagination1279 - 1283
ISSN07248741
KeywordsDrug delivery vehicle; erodible polymers; induction period; molecular weight; polyanhydride
Abstract

We report a study of the effects of polymer molecular weight on the erosion of polyanhydride copolymer matrices composed of 1,3-bis(p-carboxyphenoxy)-propane (CPP) and sebacic acid (SA) in aqueous solution. The erosion profile characteristically displays an induction period during which the erosion rate is relatively slow. The length of this period depends on the initial molecular weight of the polymer. The induction period may be characterized as a time during which a rapid decrease in polymer molecular weight occurs, the end of this period correlating with the time required for the polymer molecular weight to decrease to below a value of approximately 5000 (MW).

DOI10.1023/A:1015801216466
Short TitlePharm Res
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