Three-Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization

TitleThree-Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization
Publication TypeJournal Article
Year of Publication2012
AuthorsCulver, JC, Hoffmann, JC, Poché, RA, Slater, JH, West, JL, Dickinson, ME
JournalAdvanced Materials
Volume24
Issue17
Pagination2344 - 2348
Date Published05/2012
Keywordshydrogels; photolithography; Tissue Engineering; two-photon microscopy; vascular niche
Abstract

An image-guided micropatterning method is demonstrated for generating biomimetic hydrogel scaffolds with two-photon laser scanning photolithography. This process utilizes computational methods to directly translate three-dimensional cytoarchitectural features from labeled tissues into material structures. We use this method to pattern hydrogels that guide cellular organization by structurally and biochemically recapitulating complex vascular niche microenvironments with high pattern fidelity at the microscale.

DOI10.1002/adma.201200395
Short TitleAdv. Mater.
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