Methods in Molecular BiologyCancer NanotechnologyNanoshells for Photothermal Cancer Therapy

TitleMethods in Molecular BiologyCancer NanotechnologyNanoshells for Photothermal Cancer Therapy
Publication TypeBook Chapter
Year of Publication2010
AuthorsMorton, JG, Day, ES, Halas, N, West, JL
EditorGrobmyer, SR, Moudgil, BM
Book TitleCancer Nanotechnology
Series TitleMethods in Molecular Biology
Pagination101 - 117
PublisherHumana Press
CityTotowa, NJ
ISBN Number978-1-60761-609-2
Keywordscancer; nanoshells; photothermal therapy; tumor imaging; tumor targeting

Cancer is a leading cause of death in the United States and contributes to yearly rising health care costs. Current methods of treating cancer involve surgical removal of easily accessible tumors, radiation therapy, and chemotherapy. These methods do not always result in full treatment of the cancer and can in many cases damage healthy cells both surrounding the tissue area and systemically. Nanoshells are optically tunable core/shell nanoparticles that can be fabricated to strongly absorb in the near-infrared (NIR) region where light transmits deeply into tissue. When injected systemically, these particles have been shown to accumulate in the tumor due to the enhanced permeability and retention (EPR) effect and induce photothermal ablation of the tumor when irradiated with an NIR laser. Tumor specificity can be increased via functionalizing the nanoshell surface with tumor-targeting moieties. Nanoshells can also be made to strongly scatter light and therefore can be used in various imaging modalities such as dark-field microscopy and optical coherence tomography (OCT).

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